Read TGF-β in Human Disease

Get TGF-β in Human Disease

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Book Details :
Published on: 2013-06-18
Released on: 2013-06-18
Original language:

Transforming growth factor-β (TGF-β) is a secreted polypeptide with multifunctional properties manifested during embryonic development, adult organ physiology, and pathobiology of major diseases, including cancer and fibrotic and cardiovascular diseases. The signaling pathway of TGF-β now is rather well understood. Continuing revelations in the mechanisms of action of TGF-β provide specific mechanistic examples of how human cells lose their controlled function and behave wrongly during the development of diverse diseases. Equally important, however, is the current promise of exploiting the TGF-β pathway in combating human disease. This book comprehensively covers major areas of human disease where the involvement of TGF-β is firmly established. Simultaneously, the book highlights major gaps in knowledge and the future directions of research that can benefit human medical science. The core set of diseases where TGF-β action is well documented and are included in the book are cancer and cardiovascular and fibrotic disorders. The central aim of the book is to stimulate young scientists to enter the prolific TGF-β field and find new solutions to the problems remaining in this area of study. For this purpose the book provides authoritative educational chapters that furnish a good introduction to the field for young doctoral students, postdocs, and clinical fellows. The book also serves as a valuable reference for the aficionados in the field, who can find accessible and well-illustrated material for their teaching and lecturing activities, via which the importance of TGF-β biology is disseminated to the world of science and to the public. Diverse Roles of TGF-/Smads in Renal Fibrosis and ... Figure 1 TGF-/Smads and crosstalk pathways in renal fibrosis and inflammation. After binding to TRII TGF-1 activates the TRI-kinase which phosphorylates ... TGF beta 1 - Wikipedia Transforming growth factor beta 1 or TGF-1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that ... Pathway Central: TGF-Beta Pathway - SABiosciences Cell proliferation in somatic tissues specification of cell fate during embryogenesis differentiation and cell death are controlled by a multitude of cellcell ... Mitral Valve Disease and the Cavalier King Charles Spaniel What It Is. Mitral valve disease is a uniquely serious life-shortening problem for cavalier King Charles spaniels and is their leading cause of death. Role of Transforming Growth Factor in Human Disease Review Article. Mechanisms of Disease. Franklin H. Epstein M.D. Editor. Role of Transforming Growth Factor in Human Disease. Gerard C. Blobe M.D. Ph.D ... Salvianolic Acid B Attenuates Experimental Pulmonary ... Pulmonary fibrosis represents a group of devastating and largely irreversible disorders characterized by chronic inflammation and excessive deposition of collagen 12 ... Targeting the TGF[beta] signalling pathway in disease ... The transforming growth factor- (TGF) superfamily of cytokines which consists of TGFs activins inhibins Nodal bone morphogenetic proteins (BMPs) anti ... Transforming growth factor beta - Wikipedia Transforming growth factor beta (TGF-) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different isoforms ... Complexities of TGF- Targeted Cancer Therapy Abstract. Many advanced tumors produce excessive amounts of Transforming Growth Factor- (TGF-) which in normal epithelial cells is a potent growth inhibitor. Autophagy in Human Health and Disease NEJM Review Article. Mechanisms of Disease. Autophagy in Human Health and Disease. Augustine M.K. Choi M.D. Stefan W. Ryter Ph.D. and Beth Levine M.D.
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